Three-dimensional subcellular imaging is often hampered by diffraction limits in thick, heterogeneous tissues and invalid assumptions about data distribution and imaging systems. We introduce SSAI-3D, a weakly physics-informed, domain-shift-resistant framework that robustly achieves isotropic 3D imaging. Demonstrations in various label-free samples, plus validation on publicly available 3D datasets with unknown blurring and noise, confirm its potential for more accurate subcellular analysis.
Assistant Professor of Electrical Engineering and Computer Science
Massachusetts Institute of Technology
Sixian You is the Alfred Henry and Jean Morrison Hayes Career Development Assistant Professor in the MIT EECS department, and a Principal Investigator in the MIT Research Laboratory of Electronics.
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