Simon is director of the Image Analysis Collaboratory (IAC) and lecturer on Systems Biology at the Blavatnik Institute at Harvard Medical School. His research interests include classic image analysis, deep learning, spatial statistics, and causal inference. At the IAC he works closely with the local life-scientists—teaching, training, and collaborating on image and data analysis projects of all sizes.

Simon holds a Ph.D. in Physics from the Niels Bohr Institute at Copenhagen University (Denmark) and has since worked in Florence (Italy), Dresden (Germany), Princeton (NJ, USA), and Zurich (Switzerland). His past research spans econo-physics, optical tweezers, single-molecule biophysics, and cell migration.